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16 wrz 2021 · We simulated changes in resistance to flow or absorption of CSF and cerebral ISF to model hydrocephalus, cerebral edema, and to simulate disruption of the blood–brain barrier (BBB).
Through coordinated intercellular signaling, these cells function as a dynamic unit to tightly regulate brain blood flow, vascular function, neuroimmune responses, and waste clearance. In this chapter, we review the functions of individual NVU components, describe neurovascular coupling as a classic example of NVU function, and discuss ...
6 gru 2021 · This review is providing an overview of the structure and function of BBB and the different pathways to transport the various molecules between the blood and brain, as well as the factors that lead to BBB dysfunction, discussing some of the most significant biomarkers that may be utilized to anticipate BBB disruption.
6 mar 2019 · In this work, we compare a large body of published experimental data for transport in the brain to simulations of purely diffusive transport and simulations of combined convective and diffusive transport in the brain interstitium, incorporating current theories of perivascular influx and efflux.
27 sty 2022 · Cerebral blood flow (CBF) in whole brain images can theoretically be used to detect brain diseases and predict drug delivery paths in the cerebrovascular network. For example, Mintun et al. 6 explored the coupling of CBF and oxygen delivery using theoretical modeling with experimental data.
28 lip 2021 · This matching requires continuous regulation of cerebral blood flow (CBF), which can be categorized into four broad topics: 1) autoregulation, which describes the response of the cerebrovasculature to changes in perfusion pressure; 2) vascular reactivity to vasoactive stimuli [including carbon dioxide (CO 2)]; 3) neurovascular coupling (NVC), i ...
18 sie 2023 · In particular, the brain concentration of glucose and oxygen can be estimated an approach to obtain the probability density functions based on structural segmentation of the diffusion region using Delaunay triangulation and the spherical source diffusion field (SSDF) method (Kopylova et al. 2022).
