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13 mar 2023 · The decision to treat cold urticaria syndromes depends primarily on the underlying etiology, severity of response to cold stimulus, and how greatly it affects quality of life, including the frequency of anticipated cold exposure.
Cold urticaria (ColdU) is a common form of chronic inducible urticaria characterized by the development of wheals, angioedema or both in response to cold exposure. Recent research and guideline updates have advanced our understanding and management of ColdU.
8 lis 2023 · Cold urticaria is characterized by pruritic wheals (hives) and/or angioedema due to cutaneous mast cell degranulation and their release of proinflammatory mediators after cold exposure of the skin. Triggers include skin contact with cold objects, cold liquids, and cold air. Cold urticaria is reviewed here.
In this review, we discuss the clinical features of the various cold-induced urticaria disorders, address the clinical chal-lenge of classifying and managing the varied presentations of these diseases, and highlight the novel genes and associated molecular mechanisms underlying the disease pathogenesis.
Cold urticaria is a hypersensitivity to cold exposure (eg, wind, freezer compartments, cold water) resulting in histamine release. It usually presents as localized redness, burning, pruritus, and urticaria in the exposed areas, but may progress to a generalized systemic reaction, shock, and death.
13 lis 2021 · FRR8 RCTs evaluating the safety and efficacy of emerging treatments for people with all types of urticaria, including the new high-affinity, humanized monoclonal anti-IgE antibody ligelizumab, and potential new treatment options such as tyrosine kinase inhibitors, dupilumab, histamine H 4 receptor antagonists, C5a receptor antagonists and drugs ...
Avoidance of cold exposure is the most effective prophylactic measure. In mild to moderate cases, the primary goal of therapy is to improve the patient's quality of life. In more severe cases, treatment measures to protect the patient's airway, breathing, and circulation may be necessary.
