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16 cze 2024 · Understanding how genetics works helps in predicting the likelihood of having a cleft chin and in appreciating the diversity of chin shapes. Notable research by Bhanu and Malhotra highlights significant variation in cleft chin prevalence across populations and ages.
The genetics behind cleft chins used to be thought of as simple. Cleft chins were believed to be a dominant trait: if two parents had cleft chins, their kids could have a cleft or might not. And if two parents had smooth chins, their kids would always have smooth chins.
The genetic link. So far, researchers have identified 38 genetic markers that may affect whether or not you have a cleft chin. Many of these markers are located in or near genes that influence facial bone and skull growth.
Inheritance. Guenther (1939) found 9 cases in 5 generations, and von Meirowsky (1924) reported 25 cases in 4 generations. By casual observation, Gorlin (1982) noted it in 4 generations, and McKusick (1988) found it in 3 generations.
A chin dimple, or cleft chin, can be hereditary, and passed down in what is known as a dominant trait. Our parents each give us one version of the gene involved in this trait. The two versions are not equal: ‘dominant’ means that the inheritance of just one copy of the cleft version will give you a chin cleft of some description.
23 cze 2023 · Orofacial clefts (OFCs) are the most common congenital craniofacial anomaly seen in humans. Most OFCs are sporadic and isolated - these are thought to be multifactorial in origin. Chromosomal and...
9 lut 2023 · Orofacial clefts (OFCs) are the most common congenital craniofacial anomaly seen in humans. Most OFCs are sporadic and isolated – these are thought to be multifactorial in origin. Chromosomal and...
