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The genetics behind cleft chins used to be thought of as simple. Cleft chins were believed to be a dominant trait: if two parents had cleft chins, their kids could have a cleft or might not. And if two parents had smooth chins, their kids would always have smooth chins.
16 cze 2024 · A cleft chin, or dimpled chin, is a distinctive facial feature resulting from variations in the fusion of lower jawbones during fetal growth. Cleft chin is now known to be influenced by numerous factors such as genetics, lifestyle, and environment.
The genetic link. So far, researchers have identified 38 genetic markers that may affect whether or not you have a cleft chin. Many of these markers are located in or near genes that influence facial bone and skull growth.
A chin dimple, or cleft chin, can be hereditary, and passed down in what is known as a dominant trait. Our parents each give us one version of the gene involved in this trait. The two versions are not equal: ‘dominant’ means that the inheritance of just one copy of the cleft version will give you a chin cleft of some description.
29 lis 2023 · A cleft chin is inherited as a dominant trait. You will receive two copies of a gene at birth from either of your parents. If one copy is that of a cleft chin, you will likely have one. However, you might sometimes have a cleft chin even though neither of your parents has it.
Inheritance. Guenther (1939) found 9 cases in 5 generations, and von Meirowsky (1924) reported 25 cases in 4 generations. By casual observation, Gorlin (1982) noted it in 4 generations, and McKusick (1988) found it in 3 generations.
23 cze 2023 · Orofacial clefts (OFCs) are the most common congenital craniofacial anomaly seen in humans. Most OFCs are sporadic and isolated - these are thought to be multifactorial in origin. Chromosomal...
