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20 gru 2019 · Adverse effects are mild at therapeutic doses and are mostly limited to gastrointestinal disruptions such as nausea and diarrhea. The serious adverse effects of ciprofloxacin include prolonged QT interval, hyper or hypoglycemia, and photosensitivity. Rare interactions include drug-induced bullous pemphigoid.
28 sie 2023 · Ciprofloxacin has FDA approval to treat urinary tract infections, sexually transmitted infections (gonorrhea and chancroid), skin, bone, joint infections, prostatitis, typhoid fever, gastrointestinal infections, lower respiratory tract infections, anthrax, plague, and salmonellosis.
21 sie 2017 · One reason could be the overuse or misuse of ciprofloxacin likely to be due to wide spread availability of generic versions of ciprofloxacin. Overuse or misuse of antibiotics is known to promote bacterial resistance and is likely to limit the effectiveness of ciprofloxaxin.
30 kwi 2024 · While the goal of modifying ciprofloxacin is to improve its safety and efficacy, modifications to the chemical structure can result in unexpected toxicities or side effects. Fluoroquinolones are known for their potential to cause severe adverse effects, such as tendonitis, tendon rupture, central nervous system disturbances, and phototoxicity.
Most reports of side effects have been related to the gastrointestinal tract, such as nausea or vomiting. The incidence of adverse experiences in worldwide clinical trials has been reported to be approximately 6.4 percent.
The primary mechanism of action of ciprofloxacin is inhibition of bacterial DNA gyrase. It is a broad spectrum antibacterial drug to which most Gram-negative bacteria are highly susceptible in vitro and many Gram-positive bacteria are susceptible or moderately susceptible.
Even when antibiotic treatment (the first, second, or third attempt) does kill the infecting microbe, there are unintended negative consequences. Antibiotics invariably kill off some "friendly" antibiotic-susceptible bacteria, not causing infection, that are part of a healthy microbiome.
