Search results
Chronic pancreatitis (CP) is defined according to the recently proposed mechanistic definition as a pathological fibro-inflammatory syndrome of the pancreas in individuals with genetic, environmental, and/or other risk factors who develop persistent ...
This report defines the diagnostic criteria useful in the assessment of patients with suspected and established chronic pancreatitis. All current diagnostic procedures are reviewed and evidence based statements are provided about their utility and limitations.
3 sty 2023 · We aimed to present the incidence and risk factors for pancreatic cancer in a multicenter retrospective cohort of patients with chronic pancreatitis (CP).
28 mar 2022 · PDAC seems to be uncommon in patients with autoimmune pancreatitis, with 8 reported cases in 358 patients with autoimmune pancreatitis across 4 studies. Discussion: There is an increased risk of PDAC in patients with CP, and incidence rates increase with CP disease duration.
Signs of definitive chronic pancreatitis are parenchymal or intraductal calcifications, pancreatic fibrosis, exocrine and endocrine pancreatic insufficiency resulting in malabsorption and diabetes, pain, and an increased risk of pancreatic cancer. Quality of life (QOL) and life expectancy are also reduced.
Results: In the following domains there was strong consensus: (1) the risk of pancreatic cancer in affected individuals with hereditary pancreatitis due to inherited PRSS1 mutations is high enough to justify surveillance; (2) the risk of pancreatic cancer in patients with CP associated with SPINK1 p. N34S is not high enough to justify ...
26 sty 2023 · Simple Summary. Chronic alcoholic pancreatitis displays a cumulative risk of pancreatic cancer estimated at 4% after 15 to 20 years, this risk being higher for hereditary pancreatitis with 19% and 12% in the case of PRSS1 and SPINK1 mutations, respectively, and at an age of 60 years.
