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1 sty 2003 · Comparisons to genomic or expressed sequence data from human and other organisms, combined with in silico gene predictions, allowed us to establish a gene index for human chromosome 14.
Two copies of chromosome 14, one copy inherited from each parent, form one of the pairs. Chromosome 14 spans more than 107 million DNA building blocks (base pairs) and represents about 3.5 percent of the total DNA in cells. Identifying genes on each chromosome is an active area of genetic research.
Chromosome 14 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 14 spans about 107 million base pairs (the building material of DNA) and represents between 3 and 3.5% of the total DNA in cells.
6 lut 2003 · Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located.
Chromosomes in the nucleus are basic units of inheritance in the form of threadlike complexes that are primarily composed of deoxyribonucleic acid (DNA) and proteins including histones (Fig. 2.1) (Therman and Susman, 1993). The DNA–protein complex is referred to as chromatin.
PNMA family members are encoded by at least 15 genes localized to human chromosome 14 (PNMA1 and MOAP-1), chromosome 19 (PNMA8A-C, and CCDC8), chromosome 8 (PNMA2), and X chromosome (PNMA3, PNMA5, and PNMA6A, PNMA6B, PNMA6E, PNMA6F, PNMA7A, and PNMA7B, Table 1).
Gene function can also be ascertained by reverse genetic techniques. DNA engineering methods can be used to mutate any gene and to re-insert it into a cell's chromosomes so that it becomes a permanent part of the genome.
