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23 mar 2006 · We found that 805 (52.8%) of the genes have at least two or more variants, consisting of 738 known genes, 36 novel CDSs, 30 novel transcripts and one putative gene.
Researchers have identified genes on the short arm of chromosome 11 that are associated with particular features of WAGR syndrome. A loss of the PAX6 gene disrupts normal eye development, leading to aniridia and other eye problems, and may also affect the development of the brain.
At about 21.5 genes per megabase, chromosome 11 is one of the most gene-rich, and disease-rich, chromosomes in the human genome. More than 40% of the 856 olfactory receptor genes in the human genome are located in 28 single-gene and multi-gene clusters along the chromosome.
Each chromosome has a distinct banding pattern, and each band is numbered to help identify a particular region of a chromosome. This method of mapping a gene to a particular band of the chromosome is called cytogenetic mapping. For example, the hemoglobin beta gene (HBB) is found on chromosome 11p15.4.
3 wrz 2023 · Several genes have been identified in the 11p13 region of chromosome 11 that are involved in WAGR syndrome. One of these genes, called Wt1 (Wilms tumor 1), has been associated with the development of Wilms tumor, a type of kidney cancer that mainly affects children.
23 mar 2006 · One-quarter of the protein-coding genes shows overlap with other genes. Of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome.
21 lip 2013 · This video produced by Cold Spring Harbor Laboratories takes us on a tour of about 650,000 nucleotides from the tip of the short arm of human chromosome 11. From a distance we can discern 28 genes, denoted by red and yellow blocks.
