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In the new era of genetic profiling of tumors and targeted therapeutics, this review describes the epidemiology, pathology, molecular characteristics, and current management with ongoing clinical trials for chRCC.
1 gru 2021 · Chromophobe renal cell carcinoma (ChRCC) is the third most common renal cell carcinoma (RCC) subtype, which predominantly occurs in sporadic setting. ChRCCs are considered to originate from the intercalated cell of distal tubules with two main morphological variants, classic and eosinophilic.
9 paź 2020 · summary: Chromophobe renal cell carcinoma is the third most common grading of renalcancer, and unlike other cancers, there is no accepted prognostic pathologic system. In this study, we found that agrading system included chromophobe feature of tumor necrosis could better define outcomes for patients with renal cell carcinoma. ©
13 sie 2021 · Chromophobe renal cell carcinoma (chRCC) appearing as a small incidental renal mass in a 53-year-old man. Axial noncontrast (a) , nephrographic phase (b) , and excretory phase (c) CT images show a small solid renal mass (arrow) with enhancement less than that of the renal parenchyma.
21 lut 2019 · A renal tumour core biopsy provides histopathological con-firmation of malignancy with high sensitivity and specificity; it is especially recommended before treatment with ablative therapies [III, B] as well as in patients with metastatic disease before start-ing systemic treatment [III, B].
Clinical and pathologic features. From a pathologic perspective, the char-acteristics of ChRCC include large polyg-onal cells with abundant flocculent, pale cytoplasm (leading to the term chromo-phobe) and prominent ‘‘plant-like’’ cellular membranes.
14 sie 2023 · Abstract. Chromophobe renal cell carcinoma (ChRCC) is the second most common variant histology (non-clear cell) RCC. ChRCC is distinct from clear cell RCC (ccRCC) in terms of genetics, genomics, metabolism, cell of origin, and response to targeted and immune therapies. The pathogenesis of ChRCC remains unclear, but current data suggest two ...
