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Before recommending a lifelong regimen of choline supplementation in humans, a controlled clinical trial will be needed to ultimately determine the effectiveness and optimal dosage of choline to prevent or slow the progression of AD.
There is growing evidence suggesting choline intake might have beneficial effects on cognitive function in the elderly. However, some studies report no relationship between choline intake and cognitive function or improvement in Alzheimer’s disease patients.
7 lis 2024 · Our study highlights that moderate choline consumption is a key modifiable factor for dementia and provides a reference for recommended choline intake to prevent dementia. In light of the current findings, we recommend that future studies explore in greater depth in the following directions.
28 sie 2023 · This protocol is for a systematic review of choline intake and Alzheimer’s disease that aims to assess the comparative clinical effectiveness of choline supplementation on Alzheimer’s...
27 wrz 2019 · The current established adequate intake level of choline for adult (>19 years of age) women is 425 mg/day and 550 mg/day for adult men (“US Standing Committee on the Scientific Evaluation”, 1998).
29 wrz 2024 · Though supplementing with choline is likely safe for most people in doses less than 3.5 grams (g) daily, adequate intake (AI) is actually much lower. For pregnant women, choline supplementation appears to be safe in amounts up to 3 g daily if under 18 or 3.5 g daily if over 19 years of age.
27 wrz 2019 · Taking dietary choline supplements may help to protect the brain from Alzheimer's disease. Choline reduces the activation of microglia which, when overactivated, contribute to neuroinflammation and apoptosis associated with Alzheimer's. Choline also helps block the production of amyloid plaques.
