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10 maj 2024 · Immediate reactions classically begin within one hour of the last administered dose and may begin within minutes. However, some immediate reactions appear after one hour, particularly if the drug was administered orally or taken with food.
31 sie 2020 · Protocols for cephalosporin rapid drug desensitization include choosing a safe starting dose, typically 1/10,000 th −1/1,000,000 th of the target dose; doubling steps and allowing for a minimum of 15 minutes between steps.
6 cze 2014 · Cephalosporins can cause a range of hypersensitivity reactions, including IgE-mediated, immediate reactions. Cephalosporin allergy has been reported with use of a specific cephalosporin, as a cross-reaction between different cephalosporins or as a cross-reaction to other β-lactam antibiotics.
27 gru 2021 · CHARACTERISTICS OF IMMEDIATE HYPERSENSITIVITY. Immediate reactions to cephalosporins are believed to be type-I, immunoglobulin E (IgE)-mediated reactions and classically begin within one hour of the last administered dose.
Cephalosporin hypersensitivity was proven in 22.3% of the patients referred in our Unit, according to positive ST (51.9%) or DPT to the culprit drug (48.1%). One in 5 patients were children, and cephalosporin hypersensitivity was confirmed in 15% (47.6% of them by means of ST).
10 kwi 2019 · Rapid drug desensitization procedures are safe and effective and have been used successfully for immediate and some nonimmediate cephalosporin reactions. Many gaps in knowledge still exist regarding cephalosporin hypersensitivity.
Immediate IgE-mediated hypersensitivity reactions have been reported with use of a specific cephalosporin, as a cross-reaction between different cephalosporins or as a cross-reaction to other β-lactam antibiotics, namely, penicillin.
