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  1. Recommendations about potential, silent, and seronegative celiac disease. GFD: Gluten-free diet; HLA: Human leukocytes antigen. Silent CD is characterised by the presence of both positive serology and histology for CD in the absence of classical or non-classical symptoms.

  2. This clinical guideline addresses the management of gluten-related disorders including coeliac disease (CD), non-coeliac gluten sensitivity (NCGS) and extra-intestinal manifestations related to gluten.

  3. The treatment for CD is primarily a gluten-free diet (GFD), which requires significant patient education, motivation and follow-up. Slow-responsiveness occurs frequently, particularly in those diagnosed in adulthood.

  4. The treatment for celiac disease is primarily a gluten-free diet (GFD), which requires significant patient education, motivation, and follow-up. Non-responsive celiac disease occurs frequently, particularly in those diagnosed in adulthood.

  5. An intestinal biopsy together with positive serology represents the gold standard in diagnosing CD. In 1992, Marsh14 reviewed the intensity of mucosal damage observed in treated CD patients who were confronted with increased amounts of gluten (Fig. 1).

  6. Celiac disease is usually detected by serologic testing of celiac-specific antibodies. The diagnosis is confirmed by duodenal mucosal biopsies. Both serology and biopsy should be performed on a gluten-containing diet. The treatment for celiac disease is primarily a gluten-free diet (GFD), which requires significant patient education, motivation ...

  7. Celiac Disease. CD is an immune-mediated systemic disorder triggered by gluten and related prolamins present in wheat, barley, and rye that occur in genetically susceptible individuals who have the human leukocyte antigen (HLA)-DQ2 and/or HLA-DQ8 haplotypes.

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