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  1. Sepsis is defined as “life-threatening organ dysfunction caused by a dysregulated host response to infection.”1 While sepsis is often attributed to bacterial infections, sepsis may result from infections of any etiology, including viral infections such as COVID-19.

  2. Severe sepsis and septic shock involve an inflammatory immune response to infection and are associated with high rates of mortality. CMS aims to improve patient outcomes by encouraging proactive, comprehensive management of the infection.

  3. Objectives. This toolkit allows healthcare professionals who are interested in using the sepsis surveillance methodology from the national burden study to track healthcare facility-level sepsis incidence and outcomes using an objective definition based on clinical data.

  4. The CMS sepsis core measures detail different clinical criteria and parameters that define the qualifications for severe sepsis and septic shock. The CMS definition of severe sepsis is an infection or suspected infection with two or more SIRS criteria plus one sign of organ dysfunction (Table 3).

  5. Under the new definition, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, where organ dysfunction is defined as an increase in the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score of 2 points or more, which is associated with an in-hospital mortality greater than 10%. 1.

  6. 20 gru 2021 · 1. Rhee C, Jones TM, Hamad Y, et al; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program. Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals. JAMA Netw Open. 2019;2 (2):e187571. doi: 10.1001/jamanetworkopen.2018.7571  PubMed Google Scholar. 2.

  7. 1 cze 2024 · Abstract. Sepsis remains a complex and costly disease with high morbidity and mortality. This article discusses Sepsis-2 and Sepsis-3 definitions, highlighting the 2021 Surviving Sepsis International guidelines as well as the regulatory requirements and reimbursement for the Severe Sepsis and Septic Shock Management Bundle (SEP-1) measure.

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