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Genetic Management of CD-1® IGS Mouse Colony. Charles River uses our IGS program to manage production of the Crl:CD1(ICR) mouse. The IGS program is a management system used to minimize inbreeding and manage random genetic drift that would otherwise lead to colony divergence among colonies bred in different locations worldwide.
The CD-1 mouse is a multipurpose research animal model that can be used in such fields as toxicology (safety and efficacy testing), aging and oncology.
3 sie 2023 · We have identified millions of previously unidentified CD-1 variants with the potential to confound studies involving CD-1. We used the identified variants to construct a CD-1-specific reference genome, which can improve accuracy and reduce bias when aligning genomics data derived from CD-1 mice.
4 lip 2018 · To reduce possible confounds of differences in litters, weanling mice were randomly separated into cages of 4 mice, dependent on GM profile and sex, and raised to adults.
10 lut 2020 · Based on this data, CD-1 mice can successfully be housed for up to 14wks and groups of 3 may be the best for reducing even minor levels of aggression (i.e. wounding).
6 mar 2009 · We demonstrate that CD-1 mice have a suitable genetic structure to support high resolution mapping of both quantitative and qualitative traits. CD-1 mice thus provide a complementary, readily available and inexpensive resource to inbred mouse mapping populations.
2 wrz 2020 · The use of inbred mice housed under standardized environmental conditions has been critical in identifying immuno-pathological mechanisms in different infectious and inflammatory diseases as well as revealing new therapeutic targets for clinical trials.
