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2 maj 2024 · If your dog’s blood test shows high levels of monocytes, it could be due to several reasons. It’s important to understand that a high monocyte count, known as monocytosis, is not a disease in itself but rather an indication that your dog’s body is responding to a certain condition or stress.
3 sie 2022 · Monocytes are white blood cells that help protect your dog's body by fighting off infections and inflammation. This veterinarian-reviewed article explains the role of monocytes in dogs and what monocyte low or high levels in a blood test may indicate.
20 kwi 2021 · Flow cytometry studies have illustrated that monocyte repartitioning can distinguish chronic myelomonocytic leukemia, a prototypical neoplasm with monocytosis from other reactive or neoplastic causes.
30 mar 2018 · Monocytes leave the blood and transform into macrophages within tissues, so significant inflammation or immune-mediated disease may be present without causing monocytosis. Monocytes showing variable morphology, cytoplasmic vacuoles, and pleomorphic nuclei. Canine. Monocyte with band-shaped nucleus.
Monocytes are the largest cells (typically 15-20 μm in diameter) present in normal peripheral blood. They have abundant blue-gray cytoplasm, often with multiple, variably-sized clear vacuoles.
Causes include: parasitic diseases with a systemic phase (flea bite dermatitis, heartworm disease), feline asthma, allergic tracheobronchitis in dogs, systemic mastocytosis, allergic gastroenteritis, and disseminated eosinophilic granuloma complex in cats.
Monocytes form a link to the specific immune system by processing antigen for presentation to lymphocytes and by producing substances such as interleukin-1, which initiates fever and lymphocyte activation and stimulates early hematopoietic progenitors.
