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The actual mechanical contraction response in cardiac muscle occurs via the sliding filament model of contraction. In the sliding filament model, myosin filaments slide along actin filaments to shorten or lengthen the muscle fiber for contraction and relaxation.
9 paź 2021 · The contraction of cardiac myosin can be regulated transcriptionally by differential expression of MHC, ELC, and RLC subunits. In the adult human heart, the primary ventricular isoforms are MYH7 MHC (β-cardiac myosin), MYL3 ELC, and MYL2 RLC, whereas the primary atrial isoforms are MYH6 MHC (α-cardiac myosin), MYL4 ELC, and MYL7 RLC .
19 lip 2024 · Contraction of the heart is driven by cyclical interactions between myosin and actin filaments powered by ATP hydrolysis. The modular structure of heart muscle and the organ-level...
6 wrz 2021 · At the molecular level, contraction of heart muscle is driven by the relative sliding between arrays of myosin-containing thick filaments and actin-containing thin filaments, coupled to...
9 sty 2020 · These two structures reveal how Tm and Tn bind to actin filament and how Ca 2+ binding to TnC causes conformational changes of Tn and Tm to allow actin–myosin interactions for muscle...
3D animation of the contraction of actin (thin) filaments and a myosin (thick) filament in a sarcomere (repeating contractile unit of a myofibril) in a cardiac muscle cell.
Excitation – contraction coupling. When an action potential reaches a cardiomyocyte, a rapid increase in intracellular [Ca 2+] is triggered, which results in activation of the contractile proteins, actin and myosin (Fig. 3), resulting in sarcomeric and thus cellular shortening.
