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Cardiac desmosomes and adherens junctions, in addition to gap junctions that provide open channels for electrical communication, are traditionally described as discrete components of intercalated discs connecting adjacent cardiac cells.
4 wrz 2021 · Desmosomes are critical adhesion structures in cardiomyocytes, with mutation/loss linked to the heritable cardiac disease, arrhythmogenic right ventricular cardiomyopathy (ARVC).
17 wrz 2010 · Clinical experience and results from cellular and animal models provide insights into the intercalated disc as a functional unit and into the basic substrates that underlie pathogenesis and arrhythmogenesis of arrhythmogenic right ventricular cardiomyopathy.
1 mar 2008 · Desmosomes are intercellular junctions of epithelia and cardiac muscle. They resist mechanical stress because they adopt a strongly adhesive state in which they are said to be hyper-adhesive and which distinguishes them from other intercellular junctions; desmosomes are specialised for strong adhesion and their failure can result in diseases of ...
18 lip 2023 · Desmosomes play a vital role in providing structural integrity to tissues that experience significant mechanical tension, including the heart. Deficiencies in desmosomal proteins lead to the development of arrhythmogenic cardiomyopathy (AC).
While intercellular junctions are organized differently in cardiac and epithelial tissues, studies conducted in epithelial systems may inform our understanding of cardiac desmosomes. We explore traditional and non-traditional roles of desmosomal proteins, ranging from adhesive capacities to nuclear functions.
23 kwi 2014 · In the heart, desmosomes reside at the short axis of cardiomyocytes in structures termed intercalated discs (IDs), where they facilitate the linkage between adjacent cells.
