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Effects of caffeine on liver inflammation and fibrosis. Caffeine attenuates liver ECM accumulation and fibrosis by inhibiting canonical TGF-β-SMAD pathway and blocking the MAPK-ERK1/2 signaling pathway.
- Pharmacology of caffeine and its effects on the human body
According to some studies, caffeine consumption may cause...
- Pharmacology of Caffeine: The Main Active Compound of Coffee
Because of rapid absorption, slight binding with protein,...
- Pharmacology of caffeine and its effects on the human body
1 kwi 2024 · According to some studies, caffeine consumption may cause high liver enzymes, such as alanine transaminase (ALT) and aspartate transaminase (AST), which are indicators of healthy liver function [49]. It has also been investigated if caffeine can reduce the development of liver fibrosis, a significant contributor to chronic liver disorders [ 106 ].
18 cze 2020 · In high, toxic doses, caffeine can have severe effects on brain, heart and muscle function but has not been linked to clinically apparent liver injury. In contrast, there have been several reports of liver injury linked to use of caffeine rich energy drinks. These reports have not been very convincing and most were not well documented.
20 lip 2024 · This review focuses on two of coffee’s main bioactive compounds, i.e., caffeine and chlorogenic acids, and their effects on the progression of chronic liver diseases, demonstrating that regular coffee consumption correlates with a lower risk of the development and progression of non-alcoholic steatohepatitis, viral hepatitis, liver cirrhosis ...
1 sty 2015 · Because of rapid absorption, slight binding with protein, the alkaloid crosses intercellular barriers and is well distributed in tissues and organs. Caffeine is metabolized mainly in the liver and the crucial step (i.e., demethylation) is catalyzed by CYP1A2. The compound is eliminated by kidney excretion.
22 lip 2020 · Coffee has also consistently been associated with other aspects of liver health, including lower levels of enzymes reflecting liver damage and a lower risk of liver fibrosis and cirrhosis....
20 lip 2024 · In recent years, experimental evidence has shown that the moderate consumption of coffee (3/4 cups per day) is safe and beneficial to human health, revealing protective effects against numerous chronic metabolic diseases such as diabetes, cardiovascular, neurodegenerative, and hepatic diseases.
