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20 lip 2024 · This review focuses on two of coffee’s main bioactive compounds, i.e., caffeine and chlorogenic acids, and their effects on the progression of chronic liver diseases, demonstrating that regular coffee consumption correlates with a lower risk of the development and progression of non-alcoholic steatohepatitis, viral hepatitis, liver cirrhosis ...
18 cze 2020 · In high, toxic doses, caffeine can have severe effects on brain, heart and muscle function but has not been linked to clinically apparent liver injury. In contrast, there have been several reports of liver injury linked to use of caffeine rich energy drinks.
1 kwi 2024 · The anti-inflammatory effects of caffeine are particularly relevant to liver function. Caffeine can reduce pro-inflammatory molecules, which help in hepatoprotective benefits. In studies like the one by Arauz et al. [105], this decrease of inflammation is explained.
16 paź 2022 · In this review, we summarize and analyze the prophylactic and therapeutic effects of caffeine on various liver diseases, with an emphasis on cellular assays, animal experiments, and clinical trials.
24 lut 2022 · Our focus in this study was on key factors affecting caffeine pharmacokinetics (smoking and oral contraceptive use), caffeine-drug and caffeine-disease interactions, as well as information relevant for the metabolic phenotyping and liver function testing with caffeine.
20 lip 2024 · Some studies addressed the molecular mechanisms by which caffeine exerts beneficial effects on the liver, hypothesizing a blockade of the expression of TGF-β and its connective tissue growth factor, with a consequent decrease in the mRNA levels of these profibrogenic proteins.
27 wrz 2023 · Because key liver cells express adenosine receptors linked to liver injury, regeneration, and fibrosis, it is plausible that the biological effects of coffee are explained by effects of caffeine on adenosinergic signaling in the liver.
