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3 kwi 2019 · Today, carbon-11 is exclusively produced using the 14 N(p,α) 11 C reaction via the bombardment of nitrogen gas containing trace or small amounts of either oxygen or hydrogen with 8–17 MeV protons.
Carbon-11 or 11 C is a radioactive isotope of mass 11 of the element carbon, which has a half-life of about 20, 5 minutes decays to boron-11. The atomic nucleus of the nuclide is made up of 5 neutrons and the 6 element-specific protons.
The optimization of conditions for making a carbon-11 tracer include the late introduction of the C-11 isotope, the rapid formation and purification of the target compound, and the use of automated systems to afford a high yield of the target compound in a short time.
Carbon-11 or 11 C is a radioactive isotope of carbon that decays to boron-11. This decay mainly occurs due to positron emission, with around 0.19–0.23% of decays instead occurring by electron capture. [6] [7] It has a half-life of 20.3402(53) min. 11 C → 11 B + e + + ν e + 0.96 MeV 11 C + e − → 11 B + ν e + 1.98 MeV
25 lut 2017 · This short review aims to cover the more recent and promising developments of carbon-11 (11 C) labeling radiochemistry and its utility in the production of novel radiopharmaceuticals, with special emphasis on methods that have the greatest potential to be translated for clinical positron emission tomography (PET) imaging.
31 paź 2014 · The carbon-11 isotope is most widely produced by the proton bombardment of nitrogen-14 in a gas phase cyclotron target. 11 CO 2 is the most widely produced in target C-11 primary precursor. Methylation reactions are commonly used for the production of many of the key 11 C-tracers.
The reaction with [11 C]CO 2 forms the relative 11 C-silacarboxylate ([11 C]4) which could be protonated by adding HCl to obtain ([11 C]5).
