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It should also be bear in mind that combining antibiotics can increase the incidence of side effects and drug interactions. An accumulation of toxic effects or antagonism within certain antibiotic combinations might have a negative effect and actually worsen the patient’s outcome.
- Antibiotics for treating plague: a systematic review (executive summary ...
The aim of this review is to assess the efficacy and safety...
- Antibiotics for treating plague: a systematic review (executive summary ...
21 wrz 2019 · The aim of this review is to assess the efficacy and safety of selected antibiotics – aminoglycosides (streptomycin and gentamicin), tetracyclines, fluoroquinolones and chloramphenicol – for the treatment of the different forms of plague in humans.
21 maj 2020 · Treatment with aminoglycosides such as streptomycin or gentamicin is effective when initiated early in illness but can have serious side effects. Alternatives such as fluoroquinolones, tetracyclines, and sulfonamides are potentially safer but lack robust human data on efficacy.
21 maj 2020 · When outbreaks and sporadic cases of plague do occur, detailed reporting of patients’ treatment regimens, timing of antimicrobial administration, and patient outcomes would serve to inform clinicians and public health practitioners of treatment options for future patients with plague.
9 lis 2023 · While effective against Gram-negative bacterial infections, patients treated with aminoglycosides are at higher risk of experiencing ototoxic or nephrotoxic side effects than when treated with other drugs , requiring onerous clinical monitoring–which many low-resource health facilities in areas with the highest burden of plague are not ...
9 lis 2023 · Background. Plague is a zoonotic disease that, despite affecting humans for more than 5000 years, has historically been the subject of limited drug development activity. Drugs that are currently recommended in treatment guidelines have been approved based on animal studies alone– no pivotal clinical trials in humans have yet been completed.
15 lip 2021 · Among reported U.S. cases of primary bubonic plague, 50 (91%) of 55 patients survived when treated with aminoglycoside monotherapy (i.e., received no additional antimicrobial considered to be effective for treatment of plague).
