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Early antibiotic therapy is essential for countering the disease. Several classes of antibiotics (e.g., tetracyclines, fluoroquinolones, aminoglycosides, sulfonamides, chloramphenicol, rifamycin, and β-lactams) are active in vitro against the majority of Y. pestis strains and have demonstrated efficacy in various animal models.
21 wrz 2019 · Doxycycline is widely accepted as a monotherapy for bubonic plague; however, in some settings, there is concern that a single bacteriostatic drug might not be sufficient, and the preferred option might be treatment with an aminoglycoside or combination treatment.
15 lip 2021 · In general, treatment for bubonic and pharyngeal plague, either naturally occurring or after an intentional release of Y. pestis, is similar to pneumonic and septicemic plague. Antimicrobials with demonstrated robust in vitro and in vivo activity against Y. pestis are preferred for treatment of bubonic and pharyngeal plague (Table 2).
21 maj 2020 · Treatment with aminoglycosides such as streptomycin or gentamicin is effective when initiated early in illness but can have serious side effects. Alternatives such as fluoroquinolones, tetracyclines, and sulfonamides are potentially safer but lack robust human data on efficacy.
12 maj 2021 · Early antibiotic therapy is essential for countering the disease. Several classes of antibiotics (e.g., tetracyclines, fluoroquinolones, aminoglycosides, sulfonamides, chloramphenicol, rifamycin, and β-lactams) are active in vitro against the majority of Y. pestis strains and have demonstrated efficacy in various animal models.
21 maj 2020 · Antimicrobials currently approved by the Food and Drug Administration (FDA) for treatment of plague include streptomycin, tetracyclines, and fluoroquinolones . Additionally, gentamicin, chloramphenicol, and sulfonamides are considered effective therapies [ 6 , 11 , 13 ].
20 kwi 2023 · Treatment. Treatment for plague begins as soon as the health care provider suspects the disease. Treatment is typically done in the hospital. Antibiotics that may be used include the following: Gentamicin. Doxycycline (Monodox, Vibramycin, others). Ciprofloxacin (Cipro). Levofloxacin. Moxifloxacin (Avelox). Chloramphenicol.
