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  1. Many hemodynamically stable patients with sepsis and low acuity of illness may benefit from further work up before initiating therapy, whereas patients with septic shock warrant emergent broad-spectrum antibiotics.

  2. Severe Sepsis and Septic Shock Antibiotic Guide. Table 1: Antibiotic selection options for healthcare associated and/or immunocompromised patients. Healthcare associated: intravenous therapy, wound care, or intravenous chemotherapy within the prior 30 days, residence in a nursing home or other long-term care facility, hospitalization in an ...

  3. Sepsis patients with nosocomial infections, organ dysfunction, signs of hypoperfusion or shock (including elevated lactate) presumed to be the result of infection, and/or immunosuppression should be treated with the immediate initiation of broad-spectrum antibiotics, while stable sepsis patients can undergo a rapid clinical evaluation to identif...

  4. 6 wrz 2024 · Broad spectrum is defined as therapeutic agent(s) with sufficient activity to cover a broad range of gram-negative and positive organisms, and, if suspected, against fungi and viruses. (See 'Empiric antibiotic therapy (first hour)' above and 'Initial therapy' above.)

  5. 26 sie 2021 · The need for immediate broad-spectrum empiric antimicrobial therapy for selected patients with severe sepsis may be life-saving, but may also put pressure to overuse antibiotics and drive antibiotic resistance.

  6. Currently, it is recommended that broad spectrum antibiotics be administered within one hour of presentation in higher risk categories. But beyond the apparent benefits, broad-spectrum antibiotics can cause considerable harm, including antibiotic-associated adverse effects and antibiotic resistance.

  7. 18 cze 2024 · Give people aged 16 or over who are at high risk of severe illness or death from sepsis broad spectrum intravenous antibiotic treatment, within one hour of calculating the person’s NEWS2 score on initial assessment in the emergency department or on deterioration when in the ward.

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