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BRCA1 Germline Pathogenic Variant Carriers Management Guidelines for Healthcare Professionals. Female BRCA1 Germline Pathogenic Variant (GPV) carrier age-dependent cumulative cancer risks (95% confidence intervals) Cumulative risk for contralateral breast cancer by time since first breast cancer.
3 kwi 2020 · Providers caring for patients with breast cancer with germline BRCA1/2 mutations should discuss treatment options related to the index cancer and the increased risk of contralateral breast cancer (CBC) and new ipsilateral breast cancer.
3 kwi 2020 · For women with breast cancer who have a BRCA1/2 mutation and who have been treated or are being treated with unilateral mastectomy, CRRM should be offered. CRRM is associated with a decreased risk of CBC; there is insufficient evidence for
BRCA pathogenic or likely pathogenic variants (mutations, BRCAm) account for most identifiable he-reditary breast and ovarian cancer (HBOC) syndromes. For women who carry a BRCAm, the cumulative risk for developing breast or ovarian cancer by age 70 years is 45%e66% and 11%e41%, respectively [1,2].
This overview of clinical management guidelines is based on this patient’s positive test result for a BRCA1 gene mutation. Unless otherwise stated, medical management guidelines used here are limited to those issued by the National Comprehensive Cancer Network® (NCCN®)1 in the U.S.
BRCA1 and BRCA2 gene pathogenic variants account for most hereditary breast cancer and are increasingly used to determine eligibility for PARP inhibitor (PARPi) therapy of BRCA-related cancer.
Prostate cancer risk estimates. The estimates presented are from Nyberg et al., 2020 and Li et al., 2022. rounded to nearest whole %. Nyberg (2020) was a prospective cohort study (EMBRACE) of GPV carriers recruited via familial cancer clinics. It included 376 BRCA1 and 447 BRCA2 mutation carriers.
