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Learn about risk factors for breast cancer in men. Cancer screening for men with a BRCA1 or BRCA2 inherited gene mutation. Cancer screening tests are used to find cancer in a person who has no warning signs or symptoms. Screening may help find cancer early, when the chances of long-term survival are highest.
BRCA pathogenic or likely pathogenic variants (mutations, BRCAm) account for most identifiable he-reditary breast and ovarian cancer (HBOC) syndromes. For women who carry a BRCAm, the cumulative risk for developing breast or ovarian cancer by age 70 years is 45%e66% and 11%e41%, respectively [1,2].
2 maj 2023 · The average male has a 0.1 percent lifetime risk of developing breast cancer, but in men with BRCA mutations, the risk is much higher: 1 to 5 percent lifetime risk for men with BRCA1 mutations and 5 to 10 percent lifetime risk for men with BRCA2 mutations.
There are 3 possible results: Benign or likely benign variant (the test is negative, meaning the results are normal). The test shows normal findings with no gene mutations that increase the risk of breast cancer.
Women with a mutated BRCA gene have a higher risk of getting breast or ovarian cancer . Men with a mutated BRCA gene are at a higher risk for getting breast or prostate cancer . Not everyone who inherits a BRCA1 or BRCA2 mutation will get cancer.
21 paź 2023 · The BRCA gene test looks for changes in the BRCA1 and BRCA2 genes. Other genes also can increase the risk of breast and ovarian cancer. Some genetic tests look for these other genes in addition to the BRCA genes. A genetic test that looks at many different genes is called a multigene panel test.
Testing for inherited changes in BRCA1 and BRCA2 can give several possible results: a positive result (a harmful change in the gene is present), a negative result (no harmful gene change is present), or a gene change (variant) of uncertain significance (VUS) result.
