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The toxic effects of paracetamol have been reviewed (Flower et al., 1985). Reports on the acute toxicity, and in particular hepatotoxicity, of paracetamol have continued to appear since the reporting of the first two cases in 1966 ( Davidson & Eastham, 1966 ).
11 sty 2024 · This activity outlines the utilization, indications, administration, contraindications, and toxicity of acetaminophen, emphasizing the integral role of the interprofessional healthcare team in the care of patients using acetaminophen.
Paracetamol is well tolerat-ed drug and produces few side effects from the gastrointestinal tract, however, despite that, every year, has seen a steadily increasing number of registered cases of paracetamol-induced liver intoxication all over the world.
Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). 10 It is also used for its antipyretic effects, helping to reduce fever. 23 This drug was initially approved by the U.S. FDA in 1951 and ...
This work, in conjunction with the latest reports on the mechanism of action of paracetamol, trying to point out that it is not a panacea devoid of side effects, and indeed, especially when is taken regularly and in large doses (> 4 g/day), there is a risk of serious side effects.
Key points. •. Paracetamol is an effective analgesic, especially when administered i.v., useful in a broad range of clinical conditions. •. Its mechanism of action is yet to be fully determined, and is likely to involve a number of pain pathways. •.
Indications and mechanism of action. Paracetamol (internationally known as acetaminophen) is the most common medicine encountered in paediatric practice. It is used widely by parents and health professionals and it has analgesic and antipyretic effects.
