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16 kwi 2021 · Approved biologics for the treatment of moderate-to-severe psoriasis include tumor necrosis factor inhibitors (TNFi: infliximab, etanercept, adalimumab, certolizumab pegol), interleukin (IL)-17 inhibitors (secukinumab, ixekizumab, brodalumab), an IL-12/23 inhibitor (ustekinumab), and IL-23p19 inhibitors (guselkumab, tildrakizumab, risankizumab) ...
16 lut 2021 · To maintain response to treatment, practitioners can consider increasing the dosing regimen to 80 mg SC every 2 weeks. It is the only biologic with data and FDA labeling specifically for genital plaque psoriasis. Also, ixekizumab is the only IL-17 agent that is FDA approved for treatment of plaque psoriasis down to the age of 6 years old.
29 cze 2021 · Highly promising biologicals and small oral molecules are in the pipeline of the treatment of psoriasis. The systemic treatment armamentarium for psoriasis is expanding with very effective and safe drugs including emerging biosimilars that may offer an economic solution for patients without compromising on efficacy.
In the absence of head-to-head randomized clinical trials of treatments for moderate to severe plaque psoriasis, this study provides what we believe to be a comprehensive assessment of the comparative short-term and long-term efficacy among several novel treatments.
1 paź 2020 · The guideline covers all the new as well as the older biologics, use in children and special groups (for example those with a history of cancer), and new recommendations on what do when treatment fails, when to increase the dose of biologics, and preferred options for conception, pregnancy and breastfeeding.
16 kwi 2021 · Biologics currently approved for the treatment of psoriasis include tumor necrosis factor inhibitors, interleukin (IL)-17 inhibitors, ustekinumab (an IL-12/23 inhibitor), and IL-23 inhibitors. Data from clinical trials and studies of the safety and efficacy of biologics provide essential information for the personalization of patient care.
29 cze 2021 · The latest IL-17 and IL-23 inhibitors include bimekizumab, netakimab and mirikizumab as well as oral small molecules, such as deucravacitinib, a tyrosine kinase 2 selective inhibitor, and piclidenoson, an agonist of the Gi protein-associated A3 adenosine receptor. Additional molecules are in an early phase of development.
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