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Urine samples were collected prior to drug application, immediately before drug application, and post-dose in each treatment period. The primary efficacy evaluation included the following key...
In all simulated populations, Binosto® was dominant (more QALYs, less costs) compared to denosumab. (Table 1) The cost per QALY gained of Binosto® compared to generic alendronate and no treatment always fall below €20,000 per QALY gained. Zoledronic acid was associated with more QALY than Binosto® but the
1 lip 2017 · Alendronate. Article PDF Available. Bioequivalence of generic alendronate sodium tablets (70 mg) to Fosamax® tablets (70 mg) in fasting, healthy volunteers: A randomized, open-label, three-way,...
11 lip 2017 · Introduction. Alendronate sodium, the monosodium salt of alendronic acid, is an important member of the bisphosphonate class of drugs, which inhibits bone resorption by binding to bone surfaces and slowing down the formation of hydroxyapatite crystals.
Researchers reported an increase in BMD in the spine and hip with significantly fewer new vertebral fractures in patients using teriparatide versus alendronate in those at high risk for fracture; there was no significant difference in the two groups in the incidence of nonvertebral fractures. 96
5 lis 2019 · Alendronate belongs to the class of bisphosphonate medications and is used to treat osteoporosis and other bone-related conditions. By binding to hydroxyapatite crystals within bone, alendronate downregulates osteoclast-mediated bone reabsorption, thereby leading to a reduction in bone matrix breakdown.
Strength and limitation of this study. This review only included prospective and retrospective observational studies that derived objective prescription claim data from outside clinical trial settings, to better reflect real-world adherence and persistence to oral bisphosphonates for the treatment of osteoporosis.
