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These are lupus anticoagulant (LA), anticardiolipin antibodies (aCL) and anti-beta-2 glycoprotein I antibodies (anti-B2GPI). This review will focus on anti-B2PI and their role in APS in terms of their relationship to the putative pathogenesis of the disorder and their clinical associations.
Anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of ...
8 gru 2023 · Abstract. Antiphospholipid antibodies (aPL) are autoimmune antibodies directed toward phospholipids or phospholipid-protein complexes, particularly those containing β2-glycoprotein I (β2GPI). Persistently positive aPL accompanied by arterial or venous thrombosis, or recurrent pregnancy loss, constitutes the antiphospholipid syndrome (APS).
12 lip 2012 · The discovery that the anticardiolipin antibodies that are correlated with thrombotic complications are in reality autoantibodies that recognize β 2 GPI, which has a high affinity for cardiolipin, has been an important improvement in the development of diagnostics for the syndrome.
4 lis 2021 · Furthermore, aß2GP1 have a wide range of effects in different cellular targets that are associated with pregnancy morbidity in APS patients. These main cellular targets and their downstream effects are summarized in Figure 1 and are described in the following paragraphs. FIGURE 1. Open in figure viewer PowerPoint.
Laboratory diagnosis of APLA depends upon the detection of a lupus anticoagulant, which prolongs phospholipid-dependent anticoagulation tests, and/or anticardiolipin (aCL) and anti-β 2 -glycoprotein-1 (β2GPI) antibodies. APLA are primarily directed towards phospholipid binding proteins.
Positive results for beta-2 glycoprotein 1 (B2GPI) IgG and IgM antibodies, in association with specific clinical manifestations, may be diagnostic for antiphospholipid syndrome (APS). Low levels of B2GPIIgG or IgM antibodies, especially in the absence of other criterial phospholipid antibodies should be interpreted with a high degree of suspicion.
