Search results
Beta-2-glycoprotein I (B2GPI) binds anionic phospholipids and is considered to be the predominant antigen in APS and antibodies against B2GPI (anti-B2GPI) are recognised in the laboratory criteria for APS diagnosis.
- The role of beta-2-glycoprotein I in health and disease associating ...
Beta-2-Glycoprotein I (β2GPI) plays a number of essential...
- The role of beta-2-glycoprotein I in health and disease associating ...
Anti-beta 2 glycoprotein 1 (anti-β 2 GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of vascular thrombosis and/or recurrent pregnancy-related complications.
Beta-2-Glycoprotein I (β2GPI) plays a number of essential roles throughout the body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that possess the dual capability to up and down regulate the complement and coagulation systems depending upon external stimulus.
12 lip 2012 · The discovery that the anticardiolipin antibodies that are correlated with thrombotic complications are in reality autoantibodies that recognize β 2 GPI, which has a high affinity for cardiolipin, has been an important improvement in the development of diagnostics for the syndrome.
1 sie 2019 · Recent advances allow us to propose antibodies targeting beta-2-glycoprotein I (β 2-GPI) as the most specific antibodies associated with anti-phospholipid syndrome (APS). Therefore, there is now a crucial need for powerful biological assays to adequately monitor them.
14 paź 2021 · Anti-β-2 glycoprotein I antibodies (anti-B2GPI) are often cited as the major pathogenically relevant antibody in antiphospholipid syndrome (APS), but it is unclear if there is clinical evidence to support this theory.
21 maj 2013 · Anti-β 2 -glycoprotein I (anti-β 2 GPI) antibodies are the main antiphospholipid antibodies, along with anticardiolipin and lupus anticoagulant, that characterize the autoimmune disease antiphospholipid syndrome (APS).
