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Thalassemia is a blood disorder that affects your body’s ability to produce hemoglobin and healthy red blood cells. Types include alpha and beta thalassemia.
11 gru 2022 · Beta thalassaemia occurs when there is reduced synthesis of beta globin chains due to affected beta globin genes. Alpha thalassaemia will cause an excess of unpaired beta globin chains, and beta thalassaemia will cause an excess of unpaired alpha globin chains.
8 sie 2023 · Beta thalassemia disturbs the balance of beta and alpha hemoglobin chain formation. Patients with the beta-thalassemia major usually have larger percentages of HbF and HbA2 and absent or very low HbA. Those with beta-thalassemia minor usually have a mild elevation of HbA2 and mild decrease of HbA.
1 lut 2024 · Learn what distinguishes alpha- from beta-thalassemia and how they differ in their symptoms and outlook.
1 maj 2023 · Beta-thalassemia refers to an inherited mutation of the beta-globin gene, causing a reduced beta-globin chain of hemoglobin. The highest prevalence of beta-thalassemia mutations is in people of Mediterranean, Middle Eastern, and Asian descent.
There are different types of thalassaemia, which can be divided into alpha and beta thalassaemias. Beta thalassaemia major is the most severe type. Other types include beta thalassaemia intermedia, alpha thalassaemia major and haemoglobin H disease.
Alpha-thalassemia major results in hydrops fetalis and is often fatal at birth. Beta-thalassemia major requires lifelong transfusions starting in early childhood (often before two years of age).
