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Here, we summarize the main unique properties of α-nucleosides, for example, their higher stability compared to the β-anomer, specific parallel double-stranded structure of α-β duplex, inhibition of tumors, bacteria and malaria parasites, and other biological properties.
10 paź 2024 · The DNA replication process ensures that genetic information is accurately copied and passed on to daughter cells during cell division. This process begins at specific locations in the DNA molecule known as origins of replication.
All organisms must duplicate their DNA with extraordinary accuracy before each cell division. In this section, we explore how an elaborate “replication machine” achieves this accuracy, while duplicating DNA at rates as high as 1000 nucleotides per second.
Polymerases α, δ, and ε are most active in dividing cells, suggesting that they function in replication. In contrast, polymerase β is active in nondividing and dividing cells, suggesting that it may function primarily in the repair of DNA damage.
12 cze 2023 · Their proposed model for DNA structure explained previous observations, such as the equivalent ratios of purines and pyrimidines found in the DNA molecules. It also provided a framework for the subsequent elucidation of the mechanism involved in DNA replication.
Direct competition between two or more molecules for a single binding site facilitates hand-off of DNA and proteins during DNA processing. It allows for cell cycle-coupled regulation via timed transcription of essential protein factors.
Large, dynamic protein–nucleic acid assemblies that selectively morph between distinct conformations and compositional states underpin this critical cellular process. In this article, we discuss recent progress outlining the physical basis of replisome construction and progression in eukaryotes.
