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This chapter provides a brief overview of basic PK principles. The methods used for parameter estimation is then discussed, as applied to research and clinical set-tings. Finally, the implications of altered PK in critically ill patients are presented, with specific reference to antibiotic dosing. K. Patel (*)
Basic Concepts in Pharmacokinetics. Leon Aarons Manchester Pharmacy School University of Manchester. Objectives. Define pharmacokinetics. Describe absorption. Describe distribution. Describe elimination. Why do we study PK?
Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabo-lism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient.
This chapter will review basic concepts related to pharmacokinetics and pharmacodynamics. To make safe decisions regarding medication administration, the nurse must have a strong understanding of pharmacology, the science dealing with actions of drugs on the body.
Pharmacokinetics is essentially the study of the absorp-tion, distribution, metabolism, and excretion of drugs (1–7); that is, how the body affects the drug (Fig. 2B). It is, how-ever, also the study of associated toxicity (1–6). The scope of pharmacokinetics is not limited to healthy subjects but
10 gru 2021 · This chapter aims to introduce basic pharmacokinetic terminologies and principles underpinning a drug's life cycle in the body, from administration to elimination.
Basic Pharmacokinetics consists of two parts: textual printed materials and highly interactive computer-based presentations. Together, these provide a useful combination that makes it easy to...
