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The speckled pattern in ANA (Antinuclear Antibody) testing is one of the most common and diagnostically significant patterns, characterized by its distinctive, fine or coarse speckled appearance under a fluorescence microscope.
17 sty 2019 · Systemic lupus erythematosus (SLE): when active, usually a homogenous pattern on ANA or less commonly speckled, rim, or nucleolar when present in high enough titer to be clinically significant....
21 lut 2024 · ANA patterns can be associated with different autoimmune conditions. These patterns can range from homogenous to speckled, and each carries its own significance in terms of potential autoimmune conditions.
5 sty 2022 · Second, the nuclear dense fine-speckled (AC-2) and Topo I-like (AC-29) patterns are realigned closer to the nuclear homogeneous pattern (AC-1) to highlight their similarities in staining of both interphase nuclei and mitotic condensed chromatin.
5 sty 2022 · The International Consensus on ANA Patterns (ICAP) classifies 30 relevant patterns (AC-0 to AC-29). AC-4 (fine speckled nuclear pattern) is associated to anti-SS-A/Ro, anti-SS-B/La, and...
For example, as indicated in the "antigen association section" of ICAP website, the nuclear coarse speckled pattern (AC-5) is associated mainly with anti-Sm and anti-U1-RNP antibodies, whereas the nuclear fine speckled pattern (AC-4) has a broader target antigen association.
The variant AC-4a pattern (Panel A, myriad discrete speckled) is strongly associated with anti-SS-A/Ro60 antibodies (in human serum and as monoclonal antibodies). In contrast, the plain fine speckled pattern (Panel B, herein designated AC-4b,) is much less frequently associated with anti-SS-A/Ro60.
