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3 dni temu · Currently, research on B cell mitochondria lags behind that of T cells, and there are still many untouched aspects like the role of MQC in B cells. In this review, we highlight advances that mitochondrial biogenesis, fission and fusion, mitophagy, and mtROS in the control of B cell differentiation, activation, and immune response.
8 lip 2019 · BCR signaling has been shown to govern the initiation of transcriptional programs associated with B cell activation and fate decisions, as well as the BCR-dependent processing of...
4 kwi 2019 · Here we review current understanding of how B cell responses are initiated, the different paths to generate short- and long-lived plasma cells, germinal center cells, and memory cells, and how each path impacts antibody diversity, selectivity and affinity.
20 mar 2024 · B cell receptors (BCRs) denote antigen specificity, while corresponding cell subsets indicate B cell functionality. Since each B cell uniquely encodes this combination, physical isolation and subsequent processing of individual B cells become indispensable to identify both attributes.
1 cze 2023 · B cells can be reprogrammed into pluripotent stem cells and also can undergo transdifferentiation at the midway of cell differentiation to other cell types. Mandated expression of C/EBP in specialized B cells corresponds to their fast and effective reprogramming into macrophages, reversing the cell fate of these lymphocytes and allowing them to ...
2 sty 2019 · Here, I describe some of my personal highlights of the past year, encompassing B cell behaviour in response to antigen and in germinal centres, as well as the behaviour of plasma cells.
21 paź 2022 · In this review, we start with an overview of BCR repertoire and related sequencing technologies and summarize their current applications in immune-mediated diseases. We also underscore the challenges of this emerging field and propose promising future directions in advancing BCR repertoire exploration. Graphical abstract. Subject areas.
