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6 dni temu · Fitzsimons et al. present a comprehensive pan-cancer single-cell RNA-seq atlas of intratumoral B cells, identifying ten distinct B and plasma cell clusters. They uncover associations with checkpoint inhibitor therapy response, explore B-T cell crosstalk, validate findings with spatial data, and offer an interactive tool for further research.
21 paź 2022 · Overview of B cell receptor repertoire sequencing: Mainstream technology and performance comparison. With the advances in sequencing technology, several different strategies for BCR repertoire sequencing have emerged, including Sanger sequencing, next-generation sequencing, and single-cell sequencing (Figure 2).
12 lip 2024 · To address this question, we isolated peripheral blood B cells from healthy human donors and sequenced BCRs at bulk and single-cell levels, in addition to utilizing publicly available...
6 dni temu · Tumor-infiltrating B cells play a significant role in tumor development, progression, and prognosis, yet a comprehensive classification system is lacking. To address this gap, we present a pan-cancer single-cell RNA sequencing (scRNA-seq) atlas of tumor-infiltrating B and plasma cells across a large sample cohort.
5 lis 2021 · We developed an economic model assessing cost-effectiveness of liso-cel versus axi-cel for patients with R/R LBCL after ≥ 2 lines of therapy from a commercial United States (US) payer perspective.
29 gru 2023 · 1. Introduction. Follicular lymphoma (FL) is a common non-Hodgkin lymphoma (NHL) subtype, contributing to more than one-fifth of NHL cases in Western nations [1, 2].It is a diverse category of cancer that arises from germinal center B cells’ centrocytes and centroblasts [].Although initially indolent and often observed without treatment at diagnosis, this disease remains largely incurable.
11 paź 2024 · B cells are a subtype of lymphocyte. They form part of the adaptive immune response and mediate humoral immunity. B cells can produce high-affinity antibodies and generate immunological...
