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7 mar 2024 · Development of B cell memory is a conundrum that scientists are still exploring. Studies have been conducted in vitro and using advanced animal models to elucidate the mechanism underlying the...
- B cell-reactive triad of B cells, follicular helper and regulatory T ...
Cell biology. Abstract. Autoreactive B cells are silenced...
- B cell-reactive triad of B cells, follicular helper and regulatory T ...
4 kwi 2019 · Here we review current understanding of how B cell responses are initiated, the different paths to generate short- and long-lived plasma cells, germinal center cells, and memory cells, and how each path impacts antibody diversity, selectivity and affinity.
7 lut 2024 · Cell biology. Abstract. Autoreactive B cells are silenced through receptor editing, clonal deletion and anergy induction. Additional autoreactive B cells are ignorant because of...
8 lip 2019 · B cells. Signal transduction. Abstract. Over the past several decades, B cell antigen receptor (BCR)-induced signaling pathways have been described in extraordinary molecular detail,...
23 lip 2024 · Memory B cells (MBCs) are essential for humoral immunological memory and can emerge during both the pre-germinal center (GC) and GC phases. However, the transcription regulators governing MBC development remain poorly understood.
Here, we provide a comprehensive roadmap of human B cell maturation with single-cell transcriptomics matched with bulk and single-cell antibody repertoires to define gene expression, antibody repertoires, and clonal sharing of B cell states at single-cell resolution, including memory B cell heterogeneity that reflects diverse functional and ...
5 dni temu · The clinical implications of the divergent B cell differentiation pathways in cancer are significant. GC-derived antibody-secreting cells were associated with favorable patient outcomes, while EF-dominant responses correlated with the presence of immunoregulatory AtM B cells and poorer prognoses. 5 The formation of AtM cells has been previously linked to chronic antigen stimulation and ongoing ...
