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B cell tolerance is established at several checkpoints, during B cell development in the BM (central tolerance) as well as during B cell maturation and activation in the periphery (peripheral tolerance).
9 wrz 2008 · B-cell maturation and subset development. B cells outside the marrow are morphologically homogenous, but their cell surface phenotypes, anatomic localization, and functional properties reveal still-unfolding complexities.
25 cze 2013 · In the B cell follicle, B cells undergo affinity maturation and differentiate into antibody-producing plasma cells or long-lived memory B cells 81,82.
23 sie 2023 · During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses.
3 kwi 2017 · This paper shows that loss of BCR expression in immature B cells leads to RAG expression and L-chain gene rearrangement, which supports a role for tonic signaling in B cell maturation.
19 lip 2024 · B cells originate from hematopoietic stem cells in the bone marrow, which is the site of B-cell development and maturation (bursa of Fabricius in avian species). In the bone marrow, large numbers of B cells are produced daily, but only a small number eventually...
