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1 mar 2024 · The RAM pathway is a conserved regulatory network that controls daughter cell localization of the terminal transcription factor Ace2, which, in turn, regulates transcription of a suite of septum-degrading enzymes, including chitinases and glucanases .
1 wrz 2018 · We have developed a new mouse model that combines amyloidopathy and tauopathy with deficiency in the master regulator of homeostatic responses, the transcription factor NRF2. The study demonstrates that low-grade chronic neuroinflammation is a driver of neurodegeneration, and not just a consequence, since an antioxidant modulator of ...
Factor II (FII) deficiency (also called hypoprothrombinemia or prothrombin deficiency) is a rare coagulation disorder. People affected by this deficiency and those close to them have very little written information about it. This booklet explains the causes of FII deficiency, its symptoms and available treatments.
Another study has shown that the C5 complement deficiency in A/J mice results in rapid C. auris proliferation in target organs, with fatal outcomes, while C57BL/6J mice and mice deficient in neutrophil elastase survive high-dose C. auris intravenous challenge, even after cyclophosphamide-induced immunosuppression .
Genetic mutations underlying thrombophilia are often recognized in patients with thromboembolic episodes. However, the clinical and therapeutic implications of such findings often remain unclear. We report the first case of a dural arteriovenous fistula (DAVF) in a patient with a combined factor II and factor V Leiden mutation.
16 mar 2024 · The Ace2 transcription factor regulates chitinase (Cht1) that is required for septal plate dissolution. Consistently, Santana and O’Meara demonstrated that inactivation of Ace2 caused a cell...
15 kwi 2020 · Recent genomic and transcriptomic work has also identified a variety of gene and chromosomal features that may have conferred C. auris with several important clinical phenotypes including its drug-resistance and growth at high temperatures.
