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In this review nephrological definition are discussed in a neuro-centric manner, and the areas of key overlap between CKD and cerebrovascular pathology are discussed. The multifaceted effects of renal function on the health of the brain are also examined.
16 cze 2022 · Small cohort studies suggest that CDKN2A and phosphoinositide-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway genes are preferentially altered in metastatic renal cell carcinoma brain metastases.
22 maj 2024 · Highlights. •. This ESMO Clinical Practice Guideline provides key recommendations for managing renal cell carcinoma. •. The guideline covers imaging and diagnosis, staging and risk assessment, treatment and follow-up. •. Algorithms for the management of localised and advanced or metastatic disease are provided. •.
Cerebral bleeding risk, uremic neuropathies, sodium dysregulation with impacts on nervous system, vascular calcification, and endothelial dysfunction are the next salient areas of research that are likely to reveal key breakthroughs in renal-cerebral pathophysiology.
2 lut 2014 · Frequency and patterns of brain metastasis were determined in 246 patients with metastatic RCC at autopsy. Expression of CXCR4, CCL7 (MCP-3), CCR2 and CD68 + tumour-associated macrophages (TAMs) were analysed in a separate series of 333 primary RCC and in 48 brain metastases using immunohistochemistry.
29 paź 2024 · The article by Dobrijevic et al 1 in this issue of AJKD presents a rigorous analysis using Mendelian randomization (MR), which has particular strength to estimate causal effects, to explore the potential causal links between kidney function and cancer risk.
10 gru 2013 · Results: Fifteen percent of 246 patients with metastasising RCC had brain metastasis. High CXCR4 expression levels were found in primary RCC and brain metastases (85.7% and 91.7%, respectively).
