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The EAU and NCCN guidelines provide the only available definitions, categorizing those with clinical stage T3-4 or minimal nodal involvement as very-high risk irrespective of PSA level or biopsy Gleason score. Modern imaging with mpMRI and PET-PSMA scans plays a role in pretreatment assessment.
5 kwi 2023 · Twin gestations are associated with increased risk of pregnancy complications. However, high-quality evidence regarding the management of twin pregnancies is limited, often resulting in inconsistencies in the recommendations of various national and international professional societies.
All patients had high-risk prostate cancer classified as PSA ≥20 ng/mL, Gleason score 8-10, or ≥T3 disease. The 10-year cancer-specific survival rates were 92%, 92%, and 88% for patients receiving radical prostatectomy, EBRT and ADT, and EBRT alone, respectively (p=0.06).
16 maj 2023 · High risk prostate cancer means that tumors may be at risk of spreading beyond the prostate or have already done so. Prostate cancers are divided into one of three risk groups: low,...
21 mar 2023 · External beam radiotherapy (RT) plus ADT–abiraterone–prednisone is recommended for men with very high-risk M0 prostate cancer (defined by N1 disease or at least two risk factors among T3-T4, PSA >40 ng/ml, Gleason score 8-10) [I, B; not European Medicines Agency (EMA) or Food and Drug Administration (FDA) approved for use in M0 disease].
7 lis 2020 · Combining prostate-specific antigen density (PSAD) with the PI-RADS score may help define patients who need biopsy. In patients with negative mpMRI findings (PI-RADS 1–2), the risk of finding csPCa at subsequent SBx is usually ≤10% if the PSAD is <0.15 ng/mL/cc.
13 wrz 2016 · The European Association of Urology and National Comprehensive Cancer Network guidelines provide the only available definitions, categorizing those with clinical stage T3–4 or minimal nodal...
