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8 sty 2024 · APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints. Article 25 September 2023. Introduction. Alzheimer disease (AD) is a neurodegenerative...
18 wrz 2024 · In mice expressing human ApoE3 or ApoE4, we report that border-associated macrophages (BAMs), myeloid cells closely apposed to neocortical microvessels, are both sources and effectors of ApoE4...
2 lis 2020 · APOE4 is a strong genetic risk factor for late-onset Alzheimer’s disease. Here, the authors show that APOE4 is associated with AD features in hiPSCs-derived cerebral organoids.
The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). Emerging epidemiological evidence indicated that ApoE4 contributes to AD through inuencing β-amyloid (Aβ) deposition and clearance.
Here, we review these scientific advances and propose a cell type-specific APOE4 cascade model of AD. In this model, neuronal APOE4 emerges as a crucial pathological initiator and driver of AD pathogenesis, instigating glial responses and, ultimately, neurodegeneration.
8 kwi 2019 · This review will summarize the impact of APOE on neurons and neuronal signaling, the interactions between APOE and AD pathology, and the association with memory decline.
Recent studies are now paving the way for effective apoE4-directed AD treatment approaches. Possible therapeutic approaches targeting apoE4 Schematic presentation of the apoE4-driven...
