Search results
8 sty 2024 · APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints. Article 25 September 2023. Introduction. Alzheimer disease (AD) is a neurodegenerative...
18 wrz 2024 · We report that in ApoE4 mice perivascular macrophages are the sole source and effectors of the ApoE4 mediating the neurovascular dysfunction, enhanced white matter damage and cognitive...
31 lip 2019 · Key points. The apolipoprotein E (APOE) gene has three major allelic variants, APOE* ε 2, APOE* ε 3 and APOE* ε 4; APOE* ε 4 is associated with an increased risk and lower age of onset of...
12 wrz 2024 · Studies also showed ApoE helps clear away amyloid—a job that ApoE4, which differs from ApoE2 and ApoE3 at just two amino acids, does less efficiently. The brains of APOE4 carriers not only develop more amyloid than noncarriers, but are less able to break up plaques if they do form.
11 lip 2024 · In this study, we utilized Orbitrap Secondary Ion Mass Spectrometry (OrbiSIMS) as a chemical filtering screening tool to examine molecular alterations in ApoE4-carried neuroglioma cells compared to wild-type H4 cells.
11 cze 2019 · Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Abstract. The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). Emerging epidemiological evidence indicated that ApoE4 contributes to AD through influencing β-amyloid (Aβ) deposition and clearance.
