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8 sty 2024 · Here, we review the roles of APOE4 derived from various CNS cell types, summarize the potential mechanisms underlying the cell type-specific effects of APOE4, present a novel cell...
- Apolipoprotein E in Alzheimer’s disease trajectories and the next ...
Nature Neuroscience - This Review provides a framework for...
- Apolipoprotein E and Alzheimer disease: pathobiology and ... - Nature
Key points. The apolipoprotein E (APOE) gene has three major...
- Apolipoprotein E in Alzheimer’s disease trajectories and the next ...
19 cze 2024 · Nature Neuroscience - This Review provides a framework for incorporating APOE into Alzheimer’s disease (AD) clinical care by bridging recent advances in APOE and AD research with emerging...
31 lip 2019 · Key points. The apolipoprotein E (APOE) gene has three major allelic variants, APOE* ε 2, APOE* ε 3 and APOE* ε 4; APOE* ε 4 is associated with an increased risk and lower age of onset of...
Here, we review these scientific advances and propose a cell type-specific APOE4 cascade model of AD. In this model, neuronal APOE4 emerges as a crucial pathological initiator and driver of AD pathogenesis, instigating glial responses and, ultimately, neurodegeneration.
30 paź 2024 · Background: Apolipoprotein E (APOE = gene, ApoE = protein) is a glycoprotein involved in the biological process of lipid transportation and metabolism, contributing to lipid homeostasis. APOE has been extensively studied for its correlation with neurodegenerative diseases, in particular Alzheimer’s disease (AD), where the possession of the epsilon 4 (E4) allele is established as a risk ...
Here, we review the roles of APOE4 derived from various CNS cell types, summarize the potential mechanisms underlying the cell type-specific effects of APOE4, present a novel cell type-specific APOE4 cascade model of AD, and provide perspectives on future APOE4 research and related therapeutic developments.
2 dni temu · They demonstrate the importance of neuronal APOE and the role of both APOE4 and microglia in promoting AD pathologies. ... 5 Neuroscience Graduate Program, University of California, San Francisco ... (APOE e4/4) among patients diagnosed with Alzheimer’s disease: a systematic review and meta-analysis. Neuroepidemiology. 2012; 38:1-17. Crossref ...
