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6 maj 2024 · New data confirm that APOE4 homozygosity is a major genetic cause of Alzheimer’s disease, warranting the development of specialized research strategies, treatment approaches and clinical...
11 lip 2024 · Among them, ApoE4 is known as the strongest risk gene, with individuals carrying copies of it facing up to 12-fold increased risk of developing AD compared to ApoE4 noncarriers. Understanding the role of ApoE4 should provide insight into mechanisms that drive Alzheimer’s pathogenesis.
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD.
6 maj 2024 · The study on APOE4 homozygosity indicates a genetic variant of Alzheimer’s disease with early symptom onset and distinct biomarker progression, highlighting the need for specialized...
Redefining APOE4 homozygosity as a genetic form of Alzheimer’s disease will have a substantial effect on Alzheimer’s disease diagnosis, research and therapeutic development.
10 maj 2024 · In this paper, scientists led by Juan Fortea and Victor Montal suggest that homozygosity for APOE ε4 constitutes a genetically determinant form of AD similar to autosomal dominant forms of AD, and that their results will have compelling consequences for public health and genetic counseling.
ApoE4 increased Aβ production in human, but not in mouse, neurons. Converting ApoE4 to ApoE3 by gene editing rescued these phenotypes, indicating the specific effects of ApoE4.
