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Abstract. The inheritance of Apolipoprotein E4 (APOEε4) brings the highest genetic risk of Alzheimer’s disease (AD), arguably the highest genetic risk in human pathology. Since the discovery of the association, APOE protein isoforms have been at the center of tens of thousands of studies and reports. While, without a doubt, our knowledge ...
6 maj 2024 · New data confirm that APOE4 homozygosity is a major genetic cause of Alzheimer’s disease, warranting the development of specialized research strategies, treatment approaches and clinical trials.
6 maj 2024 · The study on APOE4 homozygosity indicates a genetic variant of Alzheimer’s disease with early symptom onset and distinct biomarker progression, highlighting the need for specialized treatment...
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD.
19 cze 2024 · APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease. Article 06 May 2024. Prediction of clinical diagnosis of Alzheimer’s disease, vascular, mixed, and all-cause...
7 wrz 2019 · Individuals with homozygosity for the apolipoprotein E (APOE) ε4 allele are in the highest risk category for late-onset Alzheimer's disease (LOAD). However, some individuals in this category do not develop LOAD beyond the age of 75 years, despite being at elevated genetic risk.
20 cze 2024 · APOE4 homozygosity represents a distinct genetic form of Alzheimer's disease (AD) rather than just a risk factor, argue the authors of a major new study analyzing data from the National Alzheimer's Coordinating Center (NACC) and five large cohorts with AD biomarkers.
