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17 lip 2024 · Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers and frailty across sexes.
31 gru 2022 · An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable successful development of novel,...
Neutralizing antibodies against IL-11 reduce renal dysfunction and extend life expectancy in some mouse models, thus proposing IL-11 as a therapeutic target for treating chronic kidney disease.
1 cze 1997 · IL-11, a pleiotropic cytokine: Exciting new effects of IL-11 on gastrointestional mucosal biology. Increased survival and multilineage hematopoietic protection from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11 (IL-11).
13 lis 2017 · Fibroblast-specific Il-11 expression causes heart and kidney fibrosis and organ failure, whereas IL-11 inhibition prevents fibroblast activation and organ fibrosis, indicating that IL-11 ...
IL11 is not detected in health but is up-regulated, as an alarmin-like response to toxic, genetic, infective, mechanical, oxidative or metabolic disease factors. IL11 signalling pathways converge to cause mesenchymal transitions and a pro-inflammatory state across cell types.
1 sty 2022 · Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also associated with several non-malignant inflammatory diseases where its function remains less well-characterized.
