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This article reviews the use of non-human animals in biomedical research from a historical viewpoint, providing an insight into the most relevant social and moral issues on this topic across time, as well as to how the current paradigm for ethically ...
21 paź 2020 · Two well-known examples clearly demonstrate why it is necessary to test drugs on animals before human trials are started. In 1937, an American company launched a product called “Elixir Sulfanilamide,” containing sulfanilamide dissolved in diethylene glycol (DEG) and flavored with raspberry.
19 sie 2022 · The contemporary pharmaceutical industry is voicing growing concerns about the translatability and reproducibility of animal models. In addition, the usefulness of certain of the required regulatory safety tests in animals is being increasingly questioned.
For method refinement, she gave examples such as humane endpoints for challenge tests in many vaccine products, improvements of methods, and in vivo testing of lower severity replacing previous more severe tests (serology instead of challenge for tetanus, diphtheria, veterinary rabies etc., and the bacterial endotoxin test in place of the ...
10 lip 2020 · Based on the authors’ experiences over the past 30 years in designing and supervising animal experiments, comprehensive guidelines for planning animal studies have been constructed, called PREPARE (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence) .
7 wrz 2011 · This two-day symposium aimed to advance the study of the ethical and scientific issues surrounding the use of animals in testing and research, with particular emphasis on the adequacy of current protections and the promise and challenges of developing alternatives to the use of animals in basic research, pharmaceutical research and development ...
5 kwi 2017 · guidelines, planning, design, animal experiments, animal research Date received: 5 April 2017; accepted: 27 June 2017 Introduction The quality of animal-based studies is under increasing scrutiny, for good scientific and ethical reasons. Studies of papers reporting animal experiments have revealed alarming deficiencies in the information ...
