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This article reviews the use of non-human animals in biomedical research from a historical viewpoint, providing an insight into the most relevant social and moral issues on this topic across time, as well as to how the current paradigm for ethically ...
21 paź 2020 · Here we present a mini-review on the development of animal testing, as well as on alternative in vitro and in silico methods, that may at least partly replace animal experiments in the near future.
19 sie 2022 · Abstract. The contemporary pharmaceutical industry is voicing growing concerns about the translatability and reproducibility of animal models. In addition, the usefulness of certain of the required regulatory safety tests in animals is being increasingly questioned.
1 sie 2023 · The FD&C Act itself was passed following a large death toll from a chemical accident, and not based on evidence suggesting human safety would be improved by testing on animal models. 1 Still, the transition to the acceptance of animal-free methods in legislation is positive news.
14 wrz 2015 · The use of nonpredictive animal experiments can cause human suffering in at least two ways: (1) by producing misleading safety and efficacy data and (2) by causing potential abandonment of useful medical treatments and misdirecting resources away from more effective testing methods.
15 paź 2019 · In this review, we summarize the current state of animals in research, highlighting three areas of concern including study design and data analysis, the inherent heterogeneity of animal and human subjects, and translation of preclinical animal trials to human clinical trials.
7 wrz 2011 · This Overview provides a brief summary of the ethical and scientific considerations regarding the use of animals in research and testing, and accompanies a Collection entitled Animals, Research, and Alternatives: Measuring Progress 50 Years Later, which aims to spur ethical and scientific advancement.
