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Anal fissure (AF) is the second most common anorectal complaint in healthcare settings. The presentation might be acute or chronic, characterised by severe pain with defaecation that persists for one to two hours. Non-surgical and surgical interventions are available based on the severity and persistence of the fissure. Objective
22 sty 2013 · A small amount of the diltiazem cream or ointment is applied to the affected area twice a day. The medicine is thought to work by helping the ring muscle (sphincter) that goes around the anus (back passage) to relax and allow blood to flow to the lining of the anus (back passage).
22 sty 2013 · How well does topical diltiazem hydrochloride work? In all, 9 studies have looked at how well diltiazem cream or ointment works for treating anal fissures. Only 1 of these studies looked at how well it worked compared with using no treatment.
How effective are topical treatments (calcium channel blockers [CCBs], nitrates, and vitamin E) for chronic anal fissures in adults?
9 wrz 2013 · The use of topical 2% diltiazem hydrochloride for treating anal fissures by lowering anal sphincter pressure has been explored in multiple clinical trials since 2000[1-5]. Diltiazem hydrochloride, a calcium channel blocker, is well known as an oral treatment for hypertension and angina.
ium-channel blocker that has been tried in several clinical studies for management of chronic anal fissure. This review focuses on the available literature data on the use of topical diltiazem (cream, gel, ointment) in the treatment of chronic anal . Roja Hadianamrei.
Topical 2 per cent diltiazem ointment used as an agent for chemical sphincterotomy for chronic anal fissure offers significant healing rates but does not have a significant side-effect profile, which may aid compliance to treatment.
